4,4-Dimethylcyclohexen-1-ylboronic acid → HCID 58994540, compound

HRID 1508119Notes

Reaction equation

HRID 1508119 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:11][CH2:12][CH2:13][CH2:14][OH:15])=[O:10])=[CH:4][C:3]=1Br.[CH3:17][C:18]1([CH3:27])[CH2:23][CH2:22][C:21](B(O)O)=[CH:20][CH2:19]1>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:11][CH2:12][CH2:13][CH2:14][OH:15])=[O:10])=[CH:4][C:3]=1[C:21]1[CH2:22][CH2:23][C:18]([CH3:27])([CH3:17])[CH2:19][CH:20]=1

Participants

4

Reactant 2

HCID 441195554,4-Dimethylcyclohexen-1-ylboronic acidHCID 58994357HCID 58994357, compound

Product 1

HCID 58994540HCID 58994540, compound

Reagents, catalysts & solvents 1

HCID 178418397HCID 178418397, compoundCatalyst

Procedure

The title compound was prepared from 2-(4-amino-3-bromo-phenyl)-N-(3-hydroxy-propyl)-acetamide (as prepared in the previous step), 4,4-dimethylcyclohexen-1-yl boronic acid and Pd(PPh3)4 according to the procedure in Example 1, step (e). Mass Spectrum (ESI, m/z): Calcd. for C19H28N2O2, 317.2 (M+H). found 317.1.

Sources & evidence

ORD record
ord-79800c91f964480fb0df5732e649302a
Source dataset
uspto-grants-2015_12
Patent number
US09221797B2

Reaction notes

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