HCID 178418634, compound → HCID 178477068, compound

HRID 1508146Notes

Reaction equation

HRID 1508146 reaction equation
[CH3:1][C:2]1([CH3:28])[CH2:7][CH2:6][C:5]([C:8]2[CH:13]=[C:12]([C:14](O)([CH3:16])[CH3:15])[CH:11]=[CH:10][C:9]=2[NH:18][C:19]([C:21]2[NH:22][CH:23]=[C:24]([C:26]#[N:27])[N:25]=2)=[O:20])=[CH:4][CH2:3]1.[C:29]([OH:32])(=[S:31])[CH3:30]>>[C:26]([C:24]1[N:25]=[C:21]([C:19]([NH:18][C:9]2[CH:10]=[CH:11][C:12]([C:14]([S:31][C:29](=[O:32])[CH3:30])([CH3:15])[CH3:16])=[CH:13][C:8]=2[C:5]2[CH2:6][CH2:7][C:2]([CH3:28])([CH3:1])[CH2:3][CH:4]=2)=[O:20])[NH:22][CH:23]=1)#[N:27]

Participants

3

Reactant 2

HCID 178418634HCID 178418634, compoundHCID 178424524HCID 178424524, compound

Product 1

HCID 178477068HCID 178477068, compound

Procedure

The title compound was prepared from 4-cyano-1H-imidazole-2-carboxylic acid [2-(4,4-dimethyl-cyclohex-1-enyl)-4-(1-hydroxy-1-methyl-ethyl)-phenyl]-amide (as prepared in Example 14, step (d)) and thioacetic acid using the conditions described in Example 70. 1H-NMR (CDCl3; 400 MHz): δ 9.73 (s, 1H), 8.29 (d, 1H, J=8.6 Hz), 7.74 (s, 1H), 7.49-7.47 (m, 1H), 7.35 (d, 1H, J=2.2 Hz), 5.79 (m, 1H), 2.32-2.28 (m, 2H), 2.20 (s, 3H), 2.11 (m, 2H), 1.86 (s, 6H), 1.59 (t, 2H, J=6.2 Hz), 1.11 (s, 6H).

Sources & evidence

ORD record
ord-7622dfc567f6443fbaa08c262eda8ca2
Source dataset
uspto-grants-2015_12
Patent number
US09221797B2

Reaction notes

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