HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine → 2-Chloro-1-iodo-3-(trifluoromethoxy)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | 1-Chloro-2-(trifluoromethoxy)benzene | HCID 2782782 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Chloro-1-iodo-3-(trifluoromethoxy)benzene | HCID 71239474 | — |
Reaction Steps
To a solution of 1-chloro-2-(trifluoromethoxy)benzene (2.54 mmol) in 10 mL THF were added 1.42 mL n-BuLi (2.5 M solution in hexane) at −78° C. After 40 min, a solution of iodine (2.8 mmol) in 2.5 mL THF was added and stirring was continued at RT overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221832B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-d14bd50822b74e6294ce6e8439c564e2 |
| Source note | uspto-grants-2015_12 |