Sodium Hydroxide → HCID 21533719, compound

HRID 1508177Notes

Reaction equation

HRID 1508177 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][CH:5]=[CH:4][C:3]=1[CH:11]([F:13])[F:12].[OH-].[Na+]>CCO.O>[Cl:1][C:2]1[C:3]([CH:11]([F:12])[F:13])=[CH:4][CH:5]=[CH:6][C:7]=1[NH2:8]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 71239400HCID 71239400, compound

Product 1

HCID 21533719HCID 21533719, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of 2-chloro-1-(difluoromethyl)-3-nitrobenzene (0.43 mmol) and SnCl2 dihydrate (0.86 mmol) in 1 mL EtOH was heated to 110° C. for 6 min in a closed vial. At RT, the mixture was diluted with water, basified with 1M NaOH solution to pH 13-14 and extracted with EtOAc (3×). The combined organic layers were washed with brine, dried over MgSO4 and concentrated in vacuo to give the desired product as brown oil;

Workup

  1. extractionextracted with EtOAc (3×)
  2. washThe combined organic layers were washed with brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-1b5faefff2be4c0b9f66f2554e71b389
Source dataset
uspto-grants-2015_12
Patent number
US09221832B2

Reaction notes

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