N-methyl-2-pyrrolidone → HCID 71239552, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2,4-dichloro-6-iodophenylacetic acid methyl ester (0.95 mmol), Zn(CN)2 (0.95 mmol) and tetrakis(triphenylphosphine)palladium (0.05 mmol) in 1.5 mL anhydrous NMP was degassed and heated under argon in a closed vial to 110° C. for 2.5 h. The reaction mixture was cooled to RT, quenched with 10% aq Na2CO3 solution and extracted with EtOAc (3×). The combined organic layers were dried over MgSO4 and concentrated in vacuo. Purification by CC using Hept/EtOAc (9/1) gives the desired product as yellow oil.

Provenance & Evidence