Furo[2,3-b]pyridin-3(2H)-one O-methyloxime → 2,3-Dihydrofuro(2,3-b)pyridin-3-amine

Participants

Reaction Steps

To a solution of furo[2,3-b]pyridin-3(2H)-one O-methyl-oxime (22.2 mmol) in 25 mL 7N NH3 in MeOH was added Actimet M Raney-Nickel (3 g) and the reaction mixture was stirred under a H2 atmosphere at 5 bar overnight. The mixture was then filtered over Celite, washed with 100 mL MeOH and concentrated in vacuo to give the title compound as brown solid;

Provenance & Evidence