HCID 71239586, compound → 3-Hydroxy-7-methylfuro[2,3-c]pyridine-2-carboxylic acid ethyl ester

HRID 1508203Notes

Reaction equation

HRID 1508203 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[O:14][C:9]2N=[N:11][CH:12]=[CH:13][C:8]=2[C:7]=1[OH:15])=[O:5])[CH3:2].[CH2:16](OC(=O)C1C=CN=C(C)C=1Cl)[CH3:17]>>[CH2:1]([O:3][C:4]([C:6]1[O:14][C:9]2=[C:16]([CH3:17])[N:11]=[CH:12][CH:13]=[C:8]2[C:7]=1[OH:15])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 71239586HCID 71239586, compoundHCID 86721905Ethyl 3-chloro-2-methylisonicotinate

Product 1

HCID 712394593-Hydroxy-7-methylfuro[2,3-c]pyridine-2-carboxylic acid ethyl ester

Procedure

This compound was prepared using a method analogous to that of 5-hydroxyfuro[2,3-c]pyridazine-6-carboxylic acid ethyl ester (A.2.3.1), 3-chloro-2-methylisonicotinic acid ethyl ester replacing 3-chloropyridazine-4-carboxylic acid ethyl ester. Purification by CC (KP-SIL™ from Biotage) using EtOAc/MeOH (8/2) gives the desired product as brown solid;

Workup

  1. customThis compound was prepared
  2. customPurification by CC (KP-SIL™ from Biotage)

Sources & evidence

ORD record
ord-6e699a3319b54649a21e59812dfca0d8
Source dataset
uspto-grants-2015_12
Patent number
US09221832B2

Reaction notes

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