反应详情

温度

90 °C

To a suspension of 7-chlorofuro[2,3-c]pyridin-3(2H)-one O-methyl oxime (1.01 mmol) (A.2.7.2) in 4 mL MeOH were added 0.56 mL of NaOMe (30% solution in MeOH). The mixture was heated to 90° C. for 12 h in a closed vessel and it was then concentrated in vacuo. Purification by CC (KP-SIL™ from Biotage) using Hept/EtOAc (9/1) gives the desired product as beige solid;

1. concentrationit was then concentrated in vacuo
2. customPurification by CC (KP-SIL™ from Biotage)