Ethyl 3-chloro-2-methylisonicotinate → 5-methylfuro[2,3-c]pyridin-3(2H)-one O-methyl oxime

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This compound was prepared using a method analogous to that of 3-chloro-2-methylisonicotinic acid ethyl ester (A.2.5.2), 5-chlorofuro[2,3-c]pyridin-3(2H)-one O-methyl oxime replacing 2,3-dichloroisonicotinic acid ethyl ester. Purification by prep HPLC, xbridge very polar method acidic gives the desired product as brown solid;

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