Ethyl 3-chloro-2-methylisonicotinate → 4-methylfuro[2,3-c]pyridin-3(2H)-one O-methyl oxime

HRID 1508226Notes

Reaction equation

HRID 1508226 reaction equation
[CH2:1](OC(=O)C1C=CN=C(C)C=1Cl)C.[CH3:14][O:15][N:16]=[C:17]1[C:25]2[C:20](=[CH:21][N:22]=[CH:23][C:24]=2Cl)[O:19][CH2:18]1>>[CH3:14][O:15][N:16]=[C:17]1[C:25]2[C:20](=[CH:21][N:22]=[CH:23][C:24]=2[CH3:1])[O:19][CH2:18]1

Participants

3

Reactant 2

HCID 86721905Ethyl 3-chloro-2-methylisonicotinateHCID 867219244-chlorofuro[2,3-c]pyridin-3(2H)-one O-methyl oxime

Product 1

HCID 867219254-methylfuro[2,3-c]pyridin-3(2H)-one O-methyl oxime

Procedure

This compound was prepared using a method analogous to that of 3-chloro-2-methylisonicotinic acid ethyl ester (A.2.5.2), 4-chlorofuro[2,3-c]pyridin-3(2H)-one O-methyl oxime replacing 2,3-dichloroisonicotinic acid ethyl ester. Purification by CC using Hept/EtOAc (9/1 to 1/1) gives a white solid;

Workup

  1. customThis compound was prepared
  2. customPurification by CC
  3. customgives a white solid

Sources & evidence

ORD record
ord-c3f611547549402cbbf216d14cca8c44
Source dataset
uspto-grants-2015_12
Patent number
US09221832B2

Reaction notes

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