Ethyl 2-chloro-6-methylnicotinate → 3-Hydroxy-6-methylfuro[2,3-b]pyridine-2-carboxylic acid ethyl ester

HRID 1508231Notes

Reaction equation

HRID 1508231 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[O:14][C:9]2[N:10]=N[CH:12]=[CH:13][C:8]=2[C:7]=1[OH:15])=[O:5])[CH3:2].[CH2:16](OC(=O)C1C=CC(C)=NC=1Cl)[CH3:17]>>[CH2:1]([O:3][C:4]([C:6]1[O:14][C:9]2=[N:10][C:16]([CH3:17])=[CH:12][CH:13]=[C:8]2[C:7]=1[OH:15])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 15574421Ethyl 2-chloro-6-methylnicotinateHCID 71239586HCID 71239586, compound

Product 1

HCID 712395013-Hydroxy-6-methylfuro[2,3-b]pyridine-2-carboxylic acid ethyl ester

Procedure

This compound was prepared using a method analogous to that of 5-hydroxyfuro[2,3-c]pyridazine-6-carboxylic acid ethyl ester (A.2.3.1), 2-chloro-6-methylnicotinic acid ethyl ester replacing 3-chloropyridazine-4-carboxylic acid ethyl ester;

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-124fa2cd4df04164a5f4f93931091147
Source dataset
uspto-grants-2015_12
Patent number
US09221832B2

Reaction notes

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