Isopropylamine → HCID 14813588, compound

HRID 1508370Notes

Reaction equation

HRID 1508370 reaction equation
[CH:1]([NH2:4])([CH3:3])[CH3:2].Cl[P:6](Cl)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C(OCC)C>[CH:1]([NH:4][P:6]([NH:4][CH:1]([CH3:3])[CH3:2])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 12573Phenyl phosphorus dichloride

Product 1

HCID 14813588HCID 14813588, compoundYield 33%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a stirred solution of isopropylamine (30 ml, 352 mmol) in diethyl ether (250 ml), dichlorophenylphosphine (9.63 ml, 71 mmol, dissolved in 50 ml diethylether) was added at 0° C. over a period of 30 min. After stirring for a total of 72 hrs the solution was filtered. The residue was washed with diethylether and the solvent was removed in vacuum. The remaining oil was distilled at 0.2 Torr/76-78° C. to give a colorless liquid with 33% yield (5.3 g). 31P {H} NMR: 49.0 ppm.

Workup

  1. filtrationwas filtered
  2. washThe residue was washed with diethylether
  3. customthe solvent was removed in vacuum
  4. distillationThe remaining oil was distilled at 0.2 Torr/76-78° C.
  5. customto give a colorless liquid with 33% yield (5.3 g)

Sources & evidence

ORD record
ord-5605adf5416746c6a9db4695b1c38119
Source dataset
uspto-grants-2015_12
Patent number
US09221856B2

Reaction notes

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