Acetic Anhydride → HCID 86608767, compound

HRID 1508378Notes

Reaction equation

HRID 1508378 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][C:12]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[N:16]([C:17](=[S:20])[NH:18][NH2:19])[N:15]=[C:14]([C:21]2[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=2[F:28])[S:13]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:35](OC(=O)C)(=[O:37])[CH3:36]>ClCCl>[C:35]([NH:19][NH:18][C:17]([N:16]1[N:15]=[C:14]([C:21]2[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=2[F:28])[S:13][C:12]1([CH2:11][CH2:10][CH2:9][NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)=[S:20])(=[O:37])[CH3:36]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 86608766HCID 86608766, compound

Product 1

HCID 86608767HCID 86608767, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-(3-tert-butoxycarbonylaminopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazole-3(2H)-carbothiohydrazide (0.016 g, 0.032 mmol) in dichloromethane (1 mL) was added acetic anhydride (0.032 g, 0.32 mmol). After stirring for 1 hour at room temperature, the reaction mixture was concentrated under reduced pressure and chromatographed (10:1 hexanes/ethyl acetate) to provide the product.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. customchromatographed (10:1 hexanes/ethyl acetate)
  3. customto provide the product

Sources & evidence

ORD record
ord-287741e7124c4e29afb7ce67c20bbce3
Source dataset
uspto-grants-2015_12
Patent number
US09221841B2

Reaction notes

Loading…