2-Pyridone → HCID 58964874, compound

HRID 15084Notes

Reaction equation

HRID 15084 reaction equation
N1C=CC=CC1=O.[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][O:16][C:17]2[CH:22]=[CH:21][N:20]([C:23]3[CH:28]=[CH:27][C:26]([O:29][CH2:30][C@H:31]4[CH2:35][CH2:34][CH2:33][N:32]4C(OC(C)(C)C)=O)=[CH:25][CH:24]=3)[C:19](=[O:43])[CH:18]=2)=[N:13][CH:14]=1>>[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][O:16][C:17]2[CH:22]=[CH:21][N:20]([C:23]3[CH:28]=[CH:27][C:26]([O:29][CH2:30][C@H:31]4[CH2:35][CH2:34][CH2:33][NH:32]4)=[CH:25][CH:24]=3)[C:19](=[O:43])[CH:18]=2)=[N:13][CH:14]=1

Participants

3

Reactant 2

HCID 88712-PyridoneHCID 58964979HCID 58964979, compound

Product 1

HCID 58964874HCID 58964874, compound

Procedure

Example 121 was repeated except that 4-[(5-chloro-2-pyridinyl)methoxy]-1-(4-{[(3R)-1-tert-butoxycarbonyl)-3-pyrrolidinyl]oxy}phenyl)-1H-pyridin-2-one was replaced with 4-[(5-chloro-2-pyridinyl)methoxy]-1-(4-{[(2R)-1-(tert-butoxycarbonyl)-2-pyrrolidinyl]methyloxy}phenyl)-1H-pyridin-2-one to provide the title compound.

Sources & evidence

ORD record
ord-e1f2d77202414f3fbb071e9583ee6a02
Source dataset
uspto-grants-2010_06
Patent number
US07732456B2

Reaction notes

Loading…