HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Oxalate → Ethyl (3-methoxyphenyl)pyruvate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Oxalate | HCID 7268 | — |
| Reactant | 3-Methoxybenzyl bromide | HCID 4067207 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Reactant | Ethyl (2-fluorophenyl)pyruvate | HCID 18370709 | — |
| Product | Ethyl (3-methoxyphenyl)pyruvate | HCID 18370264 | 74% |
Reaction Steps
The title compound was prepared as described for B4 using 3-methoxybenzyl bromide (1.5 g, 7.46 mmol), magnesium (0.199 g, 8.21 mmol) and diethyl oxalate (2.18 g, 14.92 mmol). The product was isolated in the form of colorless oil in 74% yield and used instantly in next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221860B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-6e50e5f6f09c43fbac72a8d3d4cdacfb |
| Source note | uspto-grants-2015_12 |