HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Oxalate → Ethyl (3-trifluoromethylphenyl)pyruvate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Oxalate | HCID 7268 | — |
| Reactant | 1-(Bromomethyl)-3-(trifluoromethyl)benzene | HCID 123061 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Reactant | Ethyl (2-fluorophenyl)pyruvate | HCID 18370709 | — |
| Product | Ethyl (3-trifluoromethylphenyl)pyruvate | HCID 18370921 | 78% |
Reaction Steps
The title compound was prepared as described for B4 using 3-trifluoromethylbenzyl bromide (2.5 g, 10.46 mmol), magnesium (0.280 g, 11.50 mmol) and diethyl oxalate (3.06 g, 20.92 mmol). The product was isolated in the form of colorless oil in 78% yield and use instantly in next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221860B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-cd899ce840084fc7a4219fce2c639eb4 |
| Source note | uspto-grants-2015_12 |