HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Oxalate → Ethyl (3-methylphenyl)pyruvate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Oxalate | HCID 7268 | — |
| Reactant | m-Xylyl bromide | HCID 12099 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Reactant | Ethyl (2-fluorophenyl)pyruvate | HCID 18370709 | — |
| Product | Ethyl (3-methylphenyl)pyruvate | HCID 18370163 | 72% |
Reaction Steps
The title compound was prepared as described for B4 using 3-methylbenzyl bromide (1.250 g, 6.75 mmol), magnesium (0.181 g, 7.43 mmol) and diethyl oxalate (1.974 g, 13.51 mmol). The resulting compound was isolated in the form of colorless oil in 72% yield and use instantly in next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221860B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-70fa1adfca2e47cea4bccfcb37332589 |
| Source note | uspto-grants-2015_12 |