HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Oxalate → Ethyl 3-(3-fluorophenyl)-2-oxopropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Oxalate | HCID 7268 | — |
| Reactant | 3-Bromobenzyl bromide | HCID 69979 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Reactant | Ethyl (2-fluorophenyl)pyruvate | HCID 18370709 | — |
| Product | Ethyl 3-(3-fluorophenyl)-2-oxopropanoate | HCID 18370708 | 80% |
Reaction Steps
The title compound was prepared as described for B4 using 3-bromobenzyl bromide (1.250 g, 5.00 mmol), magnesium (0.134 g, 5.50 mmol) and diethyl oxalate (1.462 g, 10.00 mmol). The product was isolated in the form of colorless oil in 80% yield and use instantly in next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221860B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-713c2869a255400e96ee55c004582c15 |
| Source note | uspto-grants-2015_12 |