HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 178494703, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | HCID 178494558 | HCID 178494558 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | HCID 178494703 | HCID 178494703 | — |
Reaction Steps
The mixture of 4-hydroxy-6-methoxymethyl-2-(methylthio) pyrimidine (10.0 g, 53.7 mmol), NCS (14.34 g, 107 mmol), DMF (10 mL) and CH2Cl2 (200 mL) was stirred at room temperature for 4 h. TLC (EtOAc/hexane 40:60) showed no starting material left. The solvent was removed. The final product was recrystallized from EtOAc. The mother liquid was purified by column chromatography on silica gel using EtOAc/hexane=40:60 as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221834B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-6cf377468ec04e0088b921166256438d |
| Source note | uspto-grants-2015_12 |