Cesium carbonate → HCID 86704605, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the title compound from Step B (1.00 g, 2.83 mmol), trimethyl boroxine (1.78 g, 14.18 mmol), Cs2CO3 (0.92 g, 2.83 mmol), and catalytic amount Pd(PPh3)4 was stirred at 140° C. under microwave for 1 h. The solvent was removed. CH2Cl2 and water were added. The organic was extracted with CH2Cl2 (3×10 mL), washed with brine and dried over Na2SO4. The residue was purified by column chromatography on silica gel Biotage 40M, eluting with EtOAc/hexane (1/9) to give as a colorless oil. 1H NMR (CDCl3, 500 MHz) δ 4.61 (s, 2H), 3.55 (s, 3H), 2.60 (s, 3H), 2.58 (s, 3H).

Provenance & Evidence