Sodium Thiosulfate → HCID 86704650, compound

Participants

Reaction Steps

To methyl 3′-[4-{[(4S,5R)-5-(3,5-dichlorophenyl)-4-methyl-2-oxo-1,3-oxazolidin-3-yl]methyl}-2-(methylsulfanyl)pyrimidin-5-yl]-4′-methoxy-2-methylbiphenyl-4-carboxylate (294 mg, 0.46 mmol) in DCM (5 mL) at 0° C. was added m-chloroperbenzoic acid (319 mg, 1.381 mmol). The reaction was allowed to warm to room temperature and was diluted with DCM and sat'd sodium thiosulfate solution. The organic was washed with sat'd NaHCO3, brine, dried (Na2SO4) concentrate before purification by column chromatography to yield methyl 3′-[4-{[(4S,5R)-5-(3,5-dichlorophenyl)-4-methyl-2-oxo-1,3-oxazolidin-3-yl]methyl}-2-(methylsulfonyl)pyrimidin-5-yl]-4′-methoxy-2-methylbiphenyl-4-carboxylate (292 mg, 0.435 mmol). LCMS calc.=670.2. found=670.2.

Provenance & Evidence