Ammonia → 3-Chlorobenzene-1-carboximidamide hydrochloride

HRID 1508699Notes

Reaction equation

HRID 1508699 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([C:9](=[NH:13])OCC)[CH:6]=[CH:7][CH:8]=1.[NH3:14]>>[ClH:2].[Cl:2][C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][CH:8]=1)[C:9]([NH2:13])=[NH:14]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 21938143Ethyl 3-chlorobenzimidate hydrochloride

Product 1

HCID 131653343-Chlorobenzene-1-carboximidamide hydrochloride

Procedure

A 18-mL vial was charged with ethyl 3-chlorobenzenecarboximidate hydrochloride (450 mg, 2 mmol, 1 eq.) and NH3 (2N in ethanol, 12 ml, 24 mmol, 12 eq.). The resulting mixture was stirred at rt overnight. The volatile material was removed under reduced pressure and the product thus obtained was forwarded to the next step without any further purification.

Workup

  1. customThe volatile material was removed under reduced pressure
  2. customthe product thus obtained
  3. customwas forwarded to the next step without any further purification

Sources & evidence

ORD record
ord-4d1cf10ee67a47b89e4b888b066b2fbe
Source dataset
uspto-grants-2015_12
Patent number
US09221843B2

Reaction notes

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