4-(1H-pyrazol-1-ylmethyl)aniline → HCID 90110601, compound

HRID 1508883Notes

Reaction equation

HRID 1508883 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH2:8][CH3:9])[N:5]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[CH:11]=2)[N:3]=1.[N:17]1([CH2:22][C:23]2[CH:29]=[CH:28][C:26]([NH2:27])=[CH:25][CH:24]=2)[CH:21]=[CH:20][CH:19]=[N:18]1>>[N:17]1([CH2:22][C:23]2[CH:29]=[CH:28][C:26]([NH:27][C:2]3[CH:7]=[C:6]([CH2:8][CH3:9])[N:5]=[C:4]([C:10]4[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[CH:11]=4)[N:3]=3)=[CH:25][CH:24]=2)[CH:21]=[CH:20][CH:19]=[N:18]1

Participants

3

Reactant 2

HCID 27644124-(1H-pyrazol-1-ylmethyl)anilineHCID 435575804-Chloro-2-(3-chlorophenyl)-6-ethylpyrimidine

Product 1

HCID 90110601HCID 90110601, compoundYield 67%

Procedure

Following General Procedure A1, 4-chloro-2-(3-chlorophenyl)-6-ethylpyrimidine (0.100 g, 0.39 mmol) was reacted with 4-((1H-pyrazol-1-yl)methyl)aniline (0.082 g, 0.47 mmol) to afford the title compound (0.067 g, 67%) as a yellow solid. MW=389.88. 1H NMR (DMSO-d6, 500 MHz) δ 9.64 (s, 1H), 8.35-8.25 (m, 2H), 7.82 (d, J=2.1 Hz, 1H), 7.69 (d, J=8.4 Hz, 2H), 7.59-7.52 (m, 2H), 7.48-7.44 (m, 1H), 7.30-7.23 (m, 2H), 6.00 (s, 1H), 6.27 (t, J=2.1 Hz, 1H), 5.30 (s, 2H), 2.67 (q, J=7.6 Hz, 2H), 1.26 (t, J=7.6 Hz, 3H); APCI MS m/z 390 [M+H]+.

Sources & evidence

ORD record
ord-051b7570d19947cba8da0deae456698b
Source dataset
uspto-grants-2015_12
Patent number
US09221843B2

Reaction notes

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