4-Aminophenethyl alcohol → HCID 90338653, compound

HRID 1508956Notes

Reaction equation

HRID 1508956 reaction equation
Cl[C:2]1[CH:7]=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]2)[N:5]=[C:4]2[CH2:21][CH2:22][CH2:23][C:3]=12.[NH2:24][C:25]1[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][OH:33])=[CH:27][CH:26]=1>>[OH:33][CH2:32][CH2:31][C:28]1[CH:29]=[CH:30][C:25]([NH:24][C:2]2[CH:7]=[C:6]([N:8]3[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]3)[N:5]=[C:4]3[CH2:21][CH2:22][CH2:23][C:3]=23)=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 669044-Aminophenethyl alcoholHCID 90338624HCID 90338624, compound

Product 1

HCID 90338653HCID 90338653, compoundYield 40%

Procedure

Following general procedure B1, tert-butyl 4-(4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)piperazine-1-carboxylate (0.050 g, 0.15 mmol) was reacted with 2-(4-aminophenyl)ethanol (0.030 g, 0.22 mmol) to afford the title compound (0.026 g, 40%) as an orange oil. MW=438.56. APCI MS m/z 439 [M+H]+.

Sources & evidence

ORD record
ord-fefc5f33c9574b93ba59731daa349c15
Source dataset
uspto-grants-2015_12
Patent number
US09221843B2

Reaction notes

Loading…