p-Aminophenylacetic acid ethyl ester → HCID 90112612, compound

HRID 1508970Notes

Reaction equation

HRID 1508970 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[S:9][C:10]([Cl:13])=[CH:11][CH:12]=2)[N:5]=[C:4]2[CH2:14][CH2:15][CH2:16][C:3]=12.[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:20][CH:19]=1>>[Cl:13][C:10]1[S:9][C:8]([C:6]2[N:5]=[C:4]3[CH2:14][CH2:15][CH2:16][C:3]3=[C:2]([NH:17][C:18]3[CH:19]=[CH:20][C:21]([CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:22][CH:23]=3)[CH:7]=2)=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 225219p-Aminophenylacetic acid ethyl esterHCID 90338494HCID 90338494, compound

Product 1

HCID 90112612HCID 90112612, compoundYield 50.6%

Procedure

Following general procedure B1, 4-chloro-2-(5-chlorothiophen-2-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine (0.030 g, 0.11 mmol) was reacted with ethyl 2-(4-aminophenyl)acetate (0.024 g, 0.13 mmol) to afford crude product (0.023 g) as an orange oil. MW=412.93. APCI MS m/z 413 [M+H]+.

Sources & evidence

ORD record
ord-ee00af14164245649789b865b33089e1
Source dataset
uspto-grants-2015_12
Patent number
US09221843B2

Reaction notes

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