2-(4-(1-aminocyclobutyl)phenyl)-3-phenyl-7,8-dihydroquinolin-5(6H)-one → 2-(4-(1-aminocyclobutyl)phenyl)-3-phenyl-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one

Participants

Reaction Steps

Following the procedure for 2-(4-(1-aminocyclobutyl)phenyl)-3-phenyl-7,8-dihydroquinolin-5(6H)-one, tert-butyl(1-(4-(5-oxo-3-phenyl-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)phenyl)cyclobutyl)carbamate (14 mg, 0.03 mmol) was reacted to afford the title compound as a white solid (14 mg, 100%). LCMS (Method A): RT=4.26 min, M-NH2=366. 1H NMR (500 MHz, MeOD): 8.06 (1H, s), 7.50 (2H, d), 7.42 (2H, d), 7.29-7.28 (3H, m), 7.20-7.18 (2H, m), 3.30 (2H, t), 2.89 (2H, t), 2.78-2.72 (2H, m), 2.59-2.54 (2H, m), 2.25-2.19 (1H, m), 2.06-2.01 (2H, m), 1.98-1.92 (3H, m).

Provenance & Evidence