2-(4-(1-aminocyclobutyl)phenyl)-3-phenyl-7,8-dihydroquinolin-5(6H)-one → 2-(4-(1-aminocyclobutyl)phenyl)-3-phenyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one

Participants

Reaction Steps

Following the procedure for 2-(4-(1-aminocyclobutyl)phenyl)-3-phenyl-7,8-dihydroquinolin-5(6H)-one, tert-butyl(1-(4-(6-methyl-5-oxo-3-phenyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)phenyl)cyclobutyl)carbamate (29 mg, 0.06 mmol) was reacted to afford the title compound (32 mg, 87%). LCMS (Method A): RT=3.76 min, M-NH2=367. 1H NMR (500 MHz, MeOD): 8.29 (1H, S), 7.49 (2H, d), 7.42 (2H, d), 7.30-7.29 (3H, m), 7.21-7.19 (m, 2H), 3.80 (2H, t), 3.30 (2H, t), 3.20 (3H, s), 2.78-2.72 (m, 2H), 2.60-2.54 (m, 2H), 2.27-2.18 (m, 1H), 2.00-1.91 (m, 1H).

Provenance & Evidence