2-(4-(1-aminocyclobutyl)phenyl)-3-phenyl-7,8-dihydroquinolin-5(6H)-one → HCID 67255639, compound

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Reaction Steps

Following the procedure for 2-(4-(1-aminocyclobutyl)phenyl)-3-phenyl-7,8-dihydroquinolin-5(6H)-one, tert-butyl(1-(4-(1-methyl-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate (37 mg, 0.08 mmol) was reacted to afford the title compound (25 mg, 78%). LCMS (Method A): RT=3.90 min, M+2H+=387. 1H NMR (500 MHz, MeOD): 7.54 (1H, S), 7.40 (2H, d), 7.37 (2H, d), 7.29-7.27 (3H, m), 7.23-7.21 (m, 2H), 4.95 (2H, s), 3.42 (3H, s), 2.77-2.71 (m, 2H), 2.59-2.53 (m, 2H), 2.26-2.17 (m, 1H), 1.99-1.90 (m, 1H).

Provenance & Evidence