1-((1H-imidazol-2-yl)methyl)-6-(4-(1-aminocyclobutyl)phenyl)-7-phenyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one → HCID 53262116, compound

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Reaction Steps

Following the procedure for 1-((1H-imidazol-2-yl)methyl)-6-(4-(1-aminocyclobutyl)phenyl)-7-phenyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one, tert-butyl(1-(4-(2-oxo-7-phenyl-1-(pyridin-3-ylmethyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate (23 mg, 0.04 mmol) was reacted to afford the title compound (27 mg, quantitative). LCMS (Method A): RT=3.48 min, M+1=464. 1H NMR (500 MHz, MeOD): 8.75 (1H, br s), 8.60 (1H, br s), 8.12 (1H, d), 7.67 (1H, s), 7.49 (1H, s), 7.40-7.36 (4H, m), 7.28-7.24 (3H, m), 7.09 (2H, d), 5.42 (2H, s), 5.12 (2H, s), 2.77-2.72 (2H, m), 2.59-2.53 (2H, m), 2.25-2.21 (1H, m), 1.98-1.94 (1H, m).

Provenance & Evidence