HCID 53261988, compound → HCID 53262117, compound

Participants

Reaction Steps

Following the procedure for 14(1H-imidazol-2-yl)methyl)-6-(4-(1-aminocyclobutyl)phenyl)-7-phenyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one, tert-butyl(1-(4-(1-(cyclobutylmethyl)-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate (8 mg, 0.02 mmol) was reacted to afford the title compound (8 mg, 97%). LCMS (Method A): RT=4.65 min, M-16=423. 1H NMR (500 MHz, MeOD): 7.56 (1H,s), 7.42-7.37 (4H,m), 7.32-7.30 (3H, m), 7.23-7.21 (2H, m), 4.97 (1H, s), 4.59 (2H, s), 4.14 (2H, d), 2.80-2.72 (3H, m), 2.59-2.53 (2H, m), 2.24-2.20 (1H, m), 2.10-2.06 (2H, m), 1.98-1.87 (5H, m).

Provenance & Evidence