HCID 53262182, compound → HCID 53262237, compound

Participants

Reaction Steps

Following the procedure for 3-(6-(4-(1-aminocyclobutyl)phenyl)-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-1-yl)propanenitrile, tert-butyl(1-(4-(1-(3-cyanopropyl)-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate (35 mg, 0.065 mmol) was reacted to afford the title compound (28 mg). 1H NMR (500 MHz, CH3OD) 7.62 (1H, s), 7.41 (2H, d), 7.39 (2H, d), 7.3 (3H, m), 7.25 (2H, m), 4.98 (2H, s), 4.19 (2H, t), 2.73-2.79 (2H, m), 2.55-2.61 (4H, m), 2.22-2.25 (1H, m), 2.10-2.25 (2H, m), 1.95-1.99 (1H, m). LCMS (Method A): RT=4.01 min, M+H+=440.2.

Provenance & Evidence