2-Bromoethanol → HCID 86683597, compound

Participants

Reaction Steps

Following the procedure for tert-butyl(1-(4-(1-(2-cyanoethyl)-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate, tert-butyl 1-(4-(2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutylcarbamate (100 mg, 0.212 mmol) was reacted with 2-bromoethanol (80 mg, 0.636 mmol) to afford the title compound (75 mg. 1H NMR (500 MHz, CDCl3): 7.47 (s, 1H), 7.23-7.29 (m, 7H), 7.16-7.19 (m, 2H), 5.04 (br, 1H), 4.89 (s, 2H), 4.12 (m, 2H), 3.94 (m, 2H), 2.37-2.48 (m, 4H), 2.37 (t, 1H), 2.05 (m, 1H), 1.81 (m, 1H), 1.2-1.43 (br, 9H).

Provenance & Evidence