HCID 53262182, compound → HCID 53262413, compound

Participants

Reaction Steps

Following the procedure for 3-(6-(4-(1-aminocyclobutyl)phenyl)-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-1-yl)propanenitrile, tert-butyl(1-(4-(3-methyl-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate (25 mg, 0.051 mmol) was reacted to afford the title compound (18.5 mg). 1H NMR (500 MHz, CD3OD): 7.37-7.42 (m, 4H), 7.34 (s, 1H), 7.28-7.30 (m, 3H), 7.18-7.20 (m, 2H), 5.03 (q, 1H), 2.73-2.79 (m, 2H), 2.56-2.60 (m, 2H), 2.20-2.26 (m, 1H), 1.96-1.99 (m, 1H), 1.65 (d, 3H). LCMS (Method D): RT=0.73 min, M+H+=386.2

Provenance & Evidence