HCID 53262182, compound → HCID 75986827, compound

Participants

Reaction Steps

Following the procedure for 3-(6-(4-(1-aminocyclobutyl)phenyl)-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-1-yl)propanenitrile, tert-butyl(1-(4-(1-(cyanomethyl)-3-methyl-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate (25 mg, 0.048 mmol) was reacted to afford the title compound (20 mg). 1H NMR (500 MHz, CH3OD) 7.71 (s, 1H), 7.45 (d, 2H), 7.39 (d, 2H), 7.32 (m, 3H), 7.26 (m, 2H), 5.14 (s, 2H), 5.10 (q, 1H), 2.74-2.80 (m, 2H), 2.55-2.61 (m, 2H), 2.22-2.26 (m, 1H), 1.96-1.99 (m, 1H), 1.71 (d, 3H). LCMS (Method D): RT=0.81 min, M+H+=425.2.

Provenance & Evidence