HCID 53262182, compound → HCID 68299621, compound

Participants

Reaction Steps

Following the procedure for 3-(6-(4-(1-aminocyclobutyl)phenyl)-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-1-yl)propanenitrile, tert-butyl(1-(4-(3-(methoxymethyl)-1-methyl-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate (35 mg, 0.066 mmol) was reacted to afford the title compound (28 mg). 1H NMR (500 MHz, CH3OD) 7.49 (s, 1H), 7.42 (d, 2H), 7.38 (d,2H), 7.31 (m, 3H), 7.25 (m, 2H), 5.19 (t, 1H), 4.02 (dd, 1H), 3.92 (dd, 1H), 3.44 (s, 3H), 2.74-2.79 (m, 2H), 2.56-2.60 (m, 2H), 2.21-2.26 (m, 1H), 1.94-1.99 (m, 1H). LCMS (Method D): RT=0.79 min, M+H+=430.2.

Provenance & Evidence