1-((1H-imidazol-2-yl)methyl)-6-(4-(1-aminocyclobutyl)phenyl)-7-phenyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one → HCID 53261680, compound

HRID 1509264Notes

Reaction equation

HRID 1509264 reaction equation
N1C=CN=C1CN1C(=O)COC2N=C(C3C=CC(C4(N)CCC4)=CC=3)C(C3C=CC=CC=3)=CC1=2.[CH3:35][N:36]1[C:41]2[CH:42]=[C:43]([C:64]3[CH:69]=[CH:68][CH:67]=[CH:66][CH:65]=3)[C:44]([C:46]3[CH:51]=[CH:50][C:49]([C:52]4([NH:56]C(=O)OC(C)(C)C)[CH2:55][CH2:54][CH2:53]4)=[CH:48][CH:47]=3)=[N:45][C:40]=2[CH2:39][NH:38][C:37]1=[O:70]>>[NH2:56][C:52]1([C:49]2[CH:48]=[CH:47][C:46]([C:44]3[C:43]([C:64]4[CH:69]=[CH:68][CH:67]=[CH:66][CH:65]=4)=[CH:42][C:41]4[N:36]([CH3:35])[C:37](=[O:70])[NH:38][CH2:39][C:40]=4[N:45]=3)=[CH:51][CH:50]=2)[CH2:53][CH2:54][CH2:55]1

Participants

3

Reactant 2

HCID 532620541-((1H-imidazol-2-yl)methyl)-6-(4-(1-aminocyclobutyl)phenyl)-7-phenyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-oneHCID 67256723HCID 67256723, compound

Product 1

HCID 53261680HCID 53261680, compoundYield 20.3%

Procedure

Following the procedure for 1-((1H-imidazol-2-yl)methyl)-6-(4-(1-aminocyclobutyl)phenyl)-7-phenyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one, tert-butyl 1-(4-(1-methyl-2-oxo-7-phenyl-1,2,3,4-tetrahydropyrido[3,2-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate (31 mg, 0.064 mmol) was reacted to afford the title compound (5 mg, 20%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-10a2001a333b4f9abb110787420ac732
Source dataset
uspto-grants-2015_12
Patent number
US09221838B2

Reaction notes

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