1-((1H-imidazol-2-yl)methyl)-6-(4-(1-aminocyclobutyl)phenyl)-7-phenyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one → HCID 67254709, compound

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Reaction Steps

Following the procedure for 1-((1H-imidazol-2-yl)methyl)-6-(4-(1-aminocyclobutyl)phenyl)-7-phenyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one, tert-butyl(1-(4-(1,5-dimethyl-2-oxo-8-phenyl-2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepin-7-yl)phenyl)cyclobutyl)carbamate (15 mg, 0.03 mmol) was reacted to afford the title compound (12 mg, 64%). LCMS (Method D): RT=0.880 min, M+1=413. 1H NMR (500 MHz, MeOD): 7.65 (1H, s), 7.53 (2H, d), 7.39 (2H, d), 7.31-7.28 (3H, m), 7.24-7.22 (2H, m), 3.73 (2H, t), 3.37 (3H, s), 3.02 (3H, s), 2.81-2.75 (2H, m), 2.68 (2H, t), 2.61-2.55 (2H, m), 2.25-2.18 (1H, m), 1.99-1.91 (1H, m).

Provenance & Evidence