1-((1H-imidazol-2-yl)methyl)-6-(4-(1-aminocyclobutyl)phenyl)-7-phenyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one → HCID 53262566, compound

Participants

Reaction Steps

Following the procedure for 1-((1H-imidazol-2-yl)methyl)-6-(4-(1-aminocyclobutyl)phenyl)-7-phenyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one, tert-butyl(1-(4-(1-methyl-2-oxo-8-phenyl-2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepin-7-yl)phenyl)cyclobutyl)carbamate (21 mg, 0.04 mmol) was reacted to afford the title compound (19 mg, 72%). LCMS (Method D): RT=0.806 min, M+1=399. 1H NMR (500 MHz, MeOD): 7.65 (1H, s), 7.47 (2H, d), 7.41 (2H, d), 7.29-7.25 (3H, m), 7.20-7.19 (2H, m), 3.86-3.84 (4H, m), 3.41 (3H, s), 2.79-2.73 (4H, m), 2.61-2.55 (2H, m), 2.25-2.18 (1H, m), 1.99-1.91 (1H, m).

Provenance & Evidence