Lawesson's reagent → HCID 87326808, compound

Participants

Reaction Steps

Tert-butyl (1-(4-(1-methyl-7-phenyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate (200 mg, 0.412 mmol) was suspended in toluene (5 ml). Lawesson's reagent (125 mg, 0.309 mmol) was added at room temperature. The resulting mixture was heated under reflux for 5 hours. After it was cooled down to room temperature, the mixture was concentrated to dryness under reduced pressure. The resulting residue was dissolved in the minimum amount of dichloromethane (1 mL) and treated with diisopropyl ether (7 mL). A yellow solid crushed out. It was filtered and dried until constant weight (200 mg, 96%). LCMS (Method A): RT=7.08 min, M+1=502.

Provenance & Evidence