Hydrochloric Acid → HCID 86674876, compound

Participants

Reaction Steps

In 10 mL of chloroform, 7.32 g of a solid of diphenyliodonium 2-pivaloyloxy-1,1-difluoroethanesulfonate (purity: 90%, equivalent to 13.0 mmol) was dissolved by stirring. The resulting solution was admixed with 26 mL of methanol and 52 mg (1.30 mmol) of sodium hydroxide, and then, reacted at room temperature for 4 hours. To the thus-obtained reaction solution, 0.145 g (1.43 mmol) of concentrated hydrochloric acid was added. The reaction solution was subsequently subjected to concentration under reduced pressure. With this, 5.35 g of the target compound was obtained as a white solid (yield: 97%, purity: 90%).

Provenance & Evidence