Acetone → (6-Allyloxy-7-methoxy-quinazolin-4-yl)-(3-chloro-4-fluoro-phenyl)-amine
Reaction equation
[CH2:29]([CH:30]=[CH2:31])[Br:32].[CH3:33][C:34](=[O:35])[CH3:36].[Cl:1][c:2]1[cH:3][c:4]([NH:9][c:10]2[n:11][cH:12][n:13][c:14]3[cH:15][c:16]([O:21][CH3:22])[c:17]([OH:20])[cH:18][c:19]23)[cH:5][cH:6][c:7]1[F:8].[K+:23].[K+:24].[O-:25][C:26]([O-:27])=[O:28]>>[Cl:1][c:2]1[cH:3][c:4]([NH:9][c:10]2[n:11][cH:12][n:13][c:14]3[cH:15][c:16]([O:21][CH3:22])[c:17]([O:20][CH2:31][CH:30]=[CH2:29])[cH:18][c:19]23)[cH:5][cH:6][c:7]1[F:8]Participants
6
Sources & evidence
- ORD record
- ord-fdbb4bd1a3584b8d80c44ffe9820c2a1
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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