Hydrochloride methanol → HCID 67321618, compound

HRID 1509449Notes

Reaction equation

[OH:1][CH:2]([CH:6]1[CH2:11][C@H:10]([N:12]([C:17]([C:19]2[N:23]([CH2:24][CH2:25][CH2:26][CH2:27][O:28][CH3:29])[C:22]3[CH:30]=[CH:31][CH:32]=[CH:33][C:21]=3[N:20]=2)=[O:18])[CH2:13][CH:14]([CH3:16])[CH3:15])[CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7]1)[CH2:3][O:4][CH3:5].CO.[ClH:43]>>[ClH:43].[ClH:43].[OH:1][CH:2]([C@H:6]1[CH2:7][NH:8][CH2:9][C@@H:10]([N:12]([CH2:13][CH:14]([CH3:16])[CH3:15])[C:17]([C:19]2[N:23]([CH2:24][CH2:25][CH2:26][CH2:27][O:28][CH3:29])[C:22]3[CH:30]=[CH:31][CH:32]=[CH:33][C:21]=3[N:20]=2)=[O:18])[CH2:11]1)[CH2:3][O:4][CH3:5]

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 70883480tert-Butyl (5S)-3-(1-hydroxy-2-methoxyethyl)-5-[{[1-(4-methoxybutyl)-1H-benzimidazol-2-yl]carbonyl}(2-methylpropyl)amino]piperidine-1-carboxylate

Product 1

HCID 67321618HCID 67321618, compound

Procedure

tert-Butyl (5S)-3-(1-hydroxy-2-methoxyethyl)-5-[{[1-(4-methoxybutyl)-1H-benzimidazol-2-yl]carbonyl}(2-methylpropyl)amino]piperidine-1-carboxylate (150 mg) was dissolved in 10-20%-hydrogen chloride methanol solution (10 ml), and the mixture was stirred at room temperature for 3 hr. The solvent was evaporated under reduced pressure to give the object product (140 mg).

Workup

customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record: ord-c70e4136f6d64ed88ff9434a4cbce3f9
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09221836B2

Reaction notes

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