Hydrogen chloride-ethyl acetate → HCID 178495052, compound

HRID 1509456Notes

Reaction equation

HRID 1509456 reaction equation
[F:1][C:2]1[C:7]2[N:8]([CH2:36][CH2:37][CH2:38][CH2:39][O:40][CH3:41])[C:9]([C:11]([N:13]([CH2:32][CH:33]([CH3:35])[CH3:34])[C@H:14]3[CH2:19][C@@H:18]([C:20]4[NH:24][CH:23]=[N:22][N:21]=4)[CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15]3)=[O:12])=[N:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.C(OCC)(=O)C.[ClH:48]>>[ClH:48].[ClH:48].[F:1][C:2]1[C:7]2[N:8]([CH2:36][CH2:37][CH2:38][CH2:39][O:40][CH3:41])[C:9]([C:11]([N:13]([CH2:32][CH:33]([CH3:34])[CH3:35])[C@H:14]3[CH2:19][C@@H:18]([C:20]4[NH:24][CH:23]=[N:22][N:21]=4)[CH2:17][NH:16][CH2:15]3)=[O:12])=[N:10][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178495050HCID 178495050, compound

Product 1

HCID 178495052HCID 178495052, compound

Procedure

tert-Butyl (3S,5R)-3-{{{7-fluoro-1-(4-methoxybutyl)-1H-benzimidazol-2-yl}carbonyl}(2-methylpropyl)amino}-5-(4H-1,2,4-triazol-3-yl)piperidine-1-carboxylate (130 mg) was dissolved in 2M hydrogen chloride-ethyl acetate (3 ml), and the mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated to give the object product (91 mg).

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-18bab9516af84da68ff7fc708e732899
Source dataset
uspto-grants-2015_12
Patent number
US09221836B2

Reaction notes

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