Hydrogen chloride-ethyl acetate → HCID 67320387, compound

HRID 1509460Notes

Reaction equation

HRID 1509460 reaction equation
[F:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]([N:13]([CH2:35][CH:36]([CH3:38])[CH3:37])[C@H:14]3[CH2:19][C@@H:18]([C:20]([N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)=[O:21])[CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15]3)=[O:12])[N:7]([CH2:39][CH2:40][CH2:41][CH2:42][O:43][CH3:44])[C:6]=2[CH:5]=[CH:4][CH:3]=1.C(OCC)(=O)C.[ClH:51]>>[ClH:51].[ClH:51].[F:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]([N:13]([CH2:35][CH:36]([CH3:37])[CH3:38])[C@H:14]3[CH2:19][C@@H:18]([C:20]([N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)=[O:21])[CH2:17][NH:16][CH2:15]3)=[O:12])[N:7]([CH2:39][CH2:40][CH2:41][CH2:42][O:43][CH3:44])[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 58355534HCID 58355534, compound

Product 1

HCID 67320387HCID 67320387, compound

Procedure

tert-Butyl (3S,5R)-3-{{{4-fluoro-1-(4-methoxybutyl)-1H-benzimidazol-2-yl}carbonyl}(2-methylpropyl)amino}-5-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate (75 mg) was dissolved in 3M hydrogen chloride-ethyl acetate (2 ml), and the mixture was stirred at room temperature for 30 min and concentrated to give the object product (67 mg).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-5103adfc1a334a62bce27a4412bb7aa9
Source dataset
uspto-grants-2015_12
Patent number
US09221836B2

Reaction notes

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