Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 15097Generated: October 26, 2026

4-Methylmorpholine → Methyl (5-chlorothiophene-2-carbonyl)alaninate

https://huagongshe.com/reaction/15097

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-MethylmorpholineHCID 7972—
ReactantO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
ReactantAlaninateHCID 5460975—
Reactant5-Chloro-3-methylthiophene-2-carboxylic acidHCID 13376220—
SolventTetrahydrofuranHCID 8028—
ProductMethyl (5-chlorothiophene-2-carbonyl)alaninateHCID 60638172—

Reaction Steps

Prepared analogously to Example 1a from methyl 5-chloro-thiophene-2-carboxylic acid and 2-aminopropionate with TBTU and NMM in THF.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07732466B2
Source datasetuspto-grants-2010_06
ORD IDord-bb1475882c98444395d60f139ca030c2
Source noteuspto-grants-2010_06