Hydrochloric Acid → HCID 178494587, compound

Participants

Reaction Steps

Tert-butyl (2S,4S)-4-(methoxymethyl)-2-[9-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,11-dihydroisochromeno[4′,3′: 6,7]naphtho[1,2-d]imidazol-2-yl]pyrrolidine-1-carboxylate (310 mg, 0.507 mmol) was treated with 2 mL 1.25N HCl in ethanol and stirred at room temperature for 2h then at 50° C. for 2h. The reaction mixture was concentrated under reduced pressure to give a dark yellow solid that was directly in the next step.

Provenance & Evidence