HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 1-(Benzyloxy)-4-bromo-2-fluorobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromo-2-fluorophenol | HCID 2724981 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 1-(Benzyloxy)-4-bromo-2-fluorobenzene | HCID 18757491 | — |
Reaction Steps
210.0 g (1.10 mol) of 4-bromo-2-fluorophenol are dissolved in 1.1 l of ethyl methyl ketone, and 175.0 g (1.27 mol) of potassium carbonate and 150.0 ml (1.26 mol) of benzyl bromide are added. The mixture is refluxed for 5 h and stirred at room temperature for 16 h. The batch is filtered, and the filtrate is concentrated to dryness. The crude product is crystallised from heptane at reduced temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08211513B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-ba3525343e674790a9ae7d071c83f747 |
| Source note | uspto-grants-2012_07 |