反应详情

3.80 g (15.3 mmol) methyl 2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionate are suspended in 15.5 ml (15.5 mmol) 1-molar aqueous sodium hydroxide solution, combined with 15 ml of ethanol and then stirred for 4 hours at ambient temperature. After evaporation i. vac. the residue is combined with ice water, extracted with diethyl ether, the aqueous phase is poured into anice/acetic acid mixture and the resulting precipitate is suction filtered. After washing with water the precipitate is dried at 60° C.

1. customAfter evaporation i
2. extractionextracted with diethyl ether
3. additionthe aqueous phase is poured into anice/acetic acid mixture
4. filtrationfiltered
5. washAfter washing with water the precipitate
6. customis dried at 60° C.