HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Aminosalicylic Acid → 5-(4-Chlorobenzyl)aminosalicylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Aminosalicylic Acid | HCID 4075 | — |
| Reactant | 1-Chloro-4-(chloromethyl)benzene | HCID 7723 | — |
| Product | 5-(4-Chlorobenzyl)aminosalicylic acid | HCID 9814207 | 53% |
Reaction Steps
By following the similar procedure in Synthesis Example 1 by using 5-aminosalicylic acid (500 mg, 3.26 mmole) and 4-chlorobenzyl chloride (630 mg, 3.91 mmole), 480 mg (53% yield) of 5-(4-chlorobenzyl)aminosalicylic acid was obtained as a white solid.:mp 227-228° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08211877B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-128b3b4e09954149a920b362c22a9eb1 |
| Source note | uspto-grants-2012_07 |