5-Aminosalicylic Acid → HCID 9926415, compound

HRID 1509829Notes

Reaction equation

HRID 1509829 reaction equation
[NH2:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([OH:11])=[CH:4][CH:3]=1.[N+:12]([C:15]1[CH:23]=[CH:22][C:18]([CH2:19][CH2:20]Br)=[CH:17][CH:16]=1)([O-:14])=[O:13]>>[N+:12]([C:15]1[CH:23]=[CH:22][C:18]([CH2:19][CH2:20][NH:1][C:2]2[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([OH:11])=[CH:4][CH:3]=2)=[CH:17][CH:16]=1)([O-:14])=[O:13]

Participants

3

Reactant 2

HCID 40755-Aminosalicylic AcidHCID 792664-Nitrophenethyl bromide

Product 1

HCID 9926415HCID 9926415, compoundYield 90.3%

Procedure

By following the similar procedure in Synthesis Example 1 by using 5-aminosalicylic acid (500 mg, 3.26 mmole) and 4-nitrophenethyl bromide (900 mg, 3.92 mmole), 890 mg (50% yield) of 5-(4-nitrophenethyl)aminosalicylic acid was obtained as a pale yellow solid.: mp 234-236° C.

Workup

  1. customin Synthesis Example 1

Sources & evidence

ORD record
ord-721241ba7c134febb34ef855b2ff8f67
Source dataset
uspto-grants-2012_07
Patent number
US08211878B2

Reaction notes

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